Retro prof in the lab University of Washington Computer Science & Engineering
 Computational Biology Capstone: Project References
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Tools and databases for analyzing genomic annotations

  1. The Genomic HyperBrowser: inferential genomics at the sequence level, Geir K Sandve, Sveinung Gundersen, Halfdan Rydbeck, Ingrid K Glad, Lars Holden, Marit Holden, Knut Liestøl, Trevor Clancy, Egil Ferkingstad, Morten Johansen, Vegard Nygaard, Eivind Tøstesen, Arnoldo Frigessi, and Eivind Hovig. Genome Biology 11:R121, 2010.
    The Genomic HyperBrowser web
    Supplementary material
    Details of statistical tests
  2. The UCSC Genome Browser database: update 2011, Fujita PA, Rhead B, Zweig AS, Hinrichs AS, Karolchik D, Cline MS, Goldman M, Barber GP, Clawson H, Coelho A, Diekhans M, Dreszer TR, Giardine BM, Harte RA, Hillman-Jackson J, Hsu F, Kirkup V, Kuhn RM, Learned K, Li CH, Meyer LR, Pohl A, Raney BJ, Rosenbloom KR, Smith KE, Haussler D, and Kent WJ. Nucleic Acids Research, 2010 Oct 18.
    Genome Browser Home
    Table Browser

Some analyses of ultraconserved elements

  1. Ultraconserved elements in the human genome, G Bejerano, M Pheasant, O Makunin, S Stephen, WJ Kent, JS Mattick, and D Haussler. Science 304:1321-1325, 2004.
  2. Close sequence comparisons are sufficient to identify human cis-regulatory elements, Shyam Prabhakar, Francis Poulin, Malak Shoukry, Veena Afzal, Edward M. Rubin, Olivier Couronne, and Len A. Pennacchio. Genome Research 16: 855-863, 2006.
  3. Ultraconservation identifies a small subset of extremely constrained developmental enhancers, Axel Visel, Shyam Prabhakar, Jennifer A Akiyama, Malak Shoukry, Keith D Lewis, Amy Holt, Ingrid Plajzer-Frick, Veena Afzal, Edward M Rubin, and Len A Pennacchio. Nature Genetics 40:158-160, 2008.
  4. Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay, Julie Z. Ni, Leslie Grate, John Paul Donohue, Christine Preston, Naomi Nobida, Georgeann O'Brien, Lily Shiue, Tyson A. Clark, John E. Blume, and Manuel Ares, Jr. Genes & Development 21:708-718, 2007.
  5. Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements, Liana F. Lareau, Maki Inada, Richard E. Green, Jordan C. Wengrod, and Steven E. Brenner. Nature 446:926-929, 19 April 2007.
  6. Algorithms for Locating Extremely Conserved Elements in Multiple Sequence Alignments, Huei-Hun Elizabeth Tseng and Martin Tompa. BMC Bioinformatics 10:432, 2009.


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