MUSCLE (3.8) multiple sequence alignment Homo_sapiens -MAAIGVHLGCTSACEAVYKDGRAGVVANDAGDRVTPAVVAYSEN-EEIVGLAAKQSRIR Synechococcus_sp_RCC307|YP_00122 MGKVVGIDLGTTNSCVSVMEGGKPTVIANAEGFRTTPSVVAYTKNQDQLVGQIAKRQAVM Bacteroides_thetaiotaomicron_ MGKIIGIDLGTTNSCVAVFEGNEPVVIANSEGKRTTPSVVAFVDGGERKVGDPAKRQAIT Shewanella_sp_MR-4|YP_733094.1 MGKIIGIDLGTTNSCVAVLDGGKARVLENAEGDRTTPSIIAYTDD-ETIVGQPAKRQAVT Yersinia_enterocolitica_subsp_en MGKIIGIDLGTTNSCVAIMDGTKARVLENSEGDRTTPSIIAYTQDGETLVGQPAKRQAVT Brucella_melitensis_biovar_Abort MAKVIGIDLGTTNSCVAVMDGKNAKVIENAEGARTTPSIIAFTDGDERLAGQPAKRQAVT Desulfotalea_psychrophila_LSv54| MGKIIGIDLGTTNSCVSVMEGGEPKVIANVEGNRTTPSVVAFADNDERLVGMIAKRQAVT :*: ** *.:* :: .. . *: * * *.**:::*: .. : .* **.. : Homo_sapiens NISNTVMKVKQILGRSSSDPQAQKYIAESKCLVIE--KNGKLRYEIDTGEETKFVNPEDV Synechococcus_sp_RCC307|YP_00122 NPDNTFYSVKRFIGRRV--DEVNEESKEVSYGVEKAGSNVKVKCPVL----DKQFAPEEV Bacteroides_thetaiotaomicron_ NPTRTIFSIKRFMGENW--DQVQKEVTRVPYKVVK-GDNNTPRVDID----GRLYTPQEI Shewanella_sp_MR-4|YP_733094.1 NPNNTFFAIKRLIGRRFKDDEVQRDVNIMPFKIIQ-ADNGDAWVESR----GNKMAPPQV Yersinia_enterocolitica_subsp_en NPQNTLFAIKRLIGRRFQDEEAQRDKDIMPYKIIA-ADNGDAWLEVK----GQKIAPPQI Brucella_melitensis_biovar_Abort NPEGTLFAVKRLIGRRYDDPMVTKDKDLVPYKIVK-GDNGDAWVEVH----GKKYSPSQI Desulfotalea_psychrophila_LSv54| NPERTVYAAKRLIGRKFTDAEVQRSQEVSPFDIVE-GISGSVAIQVE----GHKYRPAEI * *. *.::* . : . . * :: Homo_sapiens ARLIFSKMKETAHSVLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAA Synechococcus_sp_RCC307|YP_00122 SAQVLRKLAEDAGKYLGETVTQAVITVPAYFNDSQRQATKDAGKIAGLEVLRIINEPTAA Bacteroides_thetaiotaomicron_ SAMILQKMKKTAEDYLGQEVTEAVITVPAYFSDSQRQATKEAGQIAGLEVKRIVNEPTAA Shewanella_sp_MR-4|YP_733094.1 SAEILKKMKKTAEDFLGEEVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAA Yersinia_enterocolitica_subsp_en SAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAA Brucella_melitensis_biovar_Abort SAMILQKMKETAESYLGETVTQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAA Desulfotalea_psychrophila_LSv54| SAMVLGKMKQTAEEYLGEEVTEAVVTVPAYFNDSQRQATKDAGKIAGLDVKRIINEPTAA : :: *: : * . **. ..:.*:*** *.: *.:* :*.. **::* *:::**:** Homo_sapiens LLAYGIGQDSPTGKSNILVFKLGGTSLSLSVMEV----NSGIYRVLSTNTDDNIGGAHFT Synechococcus_sp_RCC307|YP_00122 ALAYGL--DKKSNER-ILVFDLGGGTFDVSVLEV----GDGVFEVLSTSGDTHLGGDDFD Bacteroides_thetaiotaomicron_ ALAYGL--DKAHKDMKIAVFDLGGGTFDISILEF----GGGVFEVLSTNGDTHLGGDDFD Shewanella_sp_MR-4|YP_733094.1 ALAYGI--DKKQGDNIVAVYDLGGGTFDISIIEIDSNDGDQTFEVLATNGDTHLGGEDFD Yersinia_enterocolitica_subsp_en ALAYGL--DKEVGNRTIAVYDLGGGTFDISIIEIDEVDGEKTFEVLATNGDTHLGGEDFD Brucella_melitensis_biovar_Abort ALAYGL--DKSEGKT-IAVYDLGGGTFDVSVLEI----GDGVFEVKSTNGDTFLGGEDFD Desulfotalea_psychrophila_LSv54| SLAYGL--DKKVEEK-IAVFDLGGGTFDVSVLEI----GDGVFEVKSTNGDTFLGGEDFD ****: *. . : *:.*** ::.:*::*. . : * :*. * :** * Homo_sapiens ETLAQYLASEFQRSFKHDVRGNARAMMKLTNSAEVAKHSLSTLGSANC---FLDSLYEG- Synechococcus_sp_RCC307|YP_00122 KVIVDHLADTFKSNEGIDLRQDKQALQRLTEAAEKAKIELSSATQSEINLPFITATPEGP Bacteroides_thetaiotaomicron_ QVIINWLVQEFKNDEGADLTQDPMALQRLKEAAEKAKIELSSSTSTEINLPYIMPVNGVP Shewanella_sp_MR-4|YP_733094.1 NRLINYLADEFKKEQGLDLRKDPLAMQRLKEAAEKAKIELSSTNQTEVNLPYITADATGP Yersinia_enterocolitica_subsp_en SRLINYLVEEFKKDQGMDLRTDPLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADGSGP Brucella_melitensis_biovar_Abort IRLVEYLVAEFKKESGIDLKNDKLALQRLKEAAEKAKIELSSSQQTEINLPFITADQTGP Desulfotalea_psychrophila_LSv54| MRIVHWLADEFKREQGIDLRSDKMALQRLKEEAEKAKMELSTTVETDINLPFITADASGP : *. *: . *: : *: .*.: ** ** .**: .:: :: . Homo_sapiens QDFDCNVSRARFELLCSPLFNKCIEAIRGLLDQNGFTADDINKVVLCGGSSRIPKLQQLI Synechococcus_sp_RCC307|YP_00122 KHLDLNLTRAKFEELAAKLIDRCKVPVEQALKDAKLASSELDEIVMVGGSTRIPSVQELV Bacteroides_thetaiotaomicron_ KHLVKTLTRAKFESLAHGLIQACLEPCKKAMSDAGLSNSDIDEVILVGGSSRIPAVQKLV Shewanella_sp_MR-4|YP_733094.1 KHLVVKITRAKLESLVEDLIIRTLEPLKVALADADLSVSDINEVILVGGQTRMPKVQEAV Yersinia_enterocolitica_subsp_en KHMNIKVTRAKLESLVEDLVNRSIEPLKVALQDAGLSVSDIQDVILVGGQTRMPMVQKKV Brucella_melitensis_biovar_Abort KHLAIKLSRAKFESLVDDLVQRTVEPCKAALKDAGLKAGEIDEVVLVGGMTRMPKIQEVV Desulfotalea_psychrophila_LSv54| KHLNIKLSRSKFETLVEDLVERTVGPCKTALKDAGLSASQIDEVILVGGMSRMPMVQKKV : : .::*:.:* * *. . : : : .:::.::: ** :*:* :*: : Homo_sapiens KDLFPAVELLNSIPPDEVIPIGAAIEAGILIGKENLLVEDSLMIECSARDILVKGVDESG Synechococcus_sp_RCC307|YP_00122 KRVT-GKDPNQTVNPDEVVAVGAAIQGGVLAGE----VKDILLLDVTP---LSLGVETLG Bacteroides_thetaiotaomicron_ EDFF-GKTPSKGVNPDEVVAVGAAVQGAVLTDE----IKGVVLLDVTP---LSMGIETLG Shewanella_sp_MR-4|YP_733094.1 TNFF-GKEPRKDVNPDEAVAVGAAIQAGVLSGD----VKDVLLLDVTP---LSLGIETMG Yersinia_enterocolitica_subsp_en ADFF-GKEPRKDVNPDEAVAIGAAVQGGVLSGE----VKDVLLLDVTP---LSLGIETMG Brucella_melitensis_biovar_Abort KAFF-GKEPHKGVNPDEVVAMGAAIQGGVLQGD----VKDVLLLDVTP---LSLGIETLG Desulfotalea_psychrophila_LSv54| VEIF-GKEPHKGVNPDEVVAIGAAIQGGVLQGD----VKDVLLLDVTP---LSLGIETLG . . : : ***.:.:***::..:* .. ::. :::: :. * *:: * Homo_sapiens ASRFTVLFPSGTPLPARRQHTLQ-APGSISSVCLELYESDGKNSAKEETKFAQVVLQDLD Synechococcus_sp_RCC307|YP_00122 GV-MTKMINRNTTVPTKKTETYSTAVDGQTNVEIHVLQGE-REMASDNKSLGTFRLDGIP Bacteroides_thetaiotaomicron_ GV-MTKLIDANTTIPARKSETFSTAADNQSEVTIHVLQGE-RPMAAQNKSIGQFNLSGIA Shewanella_sp_MR-4|YP_733094.1 SV-MTKLIEKNTTIPTKAQQVFSTADDNQSAVTIHVLQGE-RKQASANKSLGQFNLDGIE Yersinia_enterocolitica_subsp_en GV-MTPLITKNTTIPTKHSQVFSTAEDNQSAVTIHVLQGE-RKRAQDNKSLGQFNLDGIQ Brucella_melitensis_biovar_Abort GV-FTRLIERNTTIPTKKSQTFSTAEDNQSAVTIRVFQGE-REMAADNKLLGQFDLVGIP Desulfotalea_psychrophila_LSv54| GV-TTKLIEKNTTVPTKKSQVFSTAADNQPAVSIHVLQGE-REMAEGNKTIGRFELADIP . * :: .*.:*:. . . * .. . * : : :.: . * :. :. . * .: Homo_sapiens KKENGLRDILAVLTMKRDGSLHVTCTDQETGKCEAISIEIAS------------------ Synechococcus_sp_RCC307|YP_00122 PAPRGVPQIEVTFDIDANGILSVTAKDKGSGKEQTISITGASTLSDNEVEKMVKDAEVNA Bacteroides_thetaiotaomicron_ PARRGVPQIEVTFDIDANGILKVSAKDKATGKEQAIRIEASSGLSKEEIEKMKAEAEANA Shewanella_sp_MR-4|YP_733094.1 PAPRGMPQIEVMFDIDADGILHVSATDKKTGKKQNITIKASSGLSEEEVAQMVRDAEAHA Yersinia_enterocolitica_subsp_en PAPRGMAQIEVTFDIDADGILHVSAKDKNTGREQKITIKASSGLNEEEIQKMVRDAEANA Brucella_melitensis_biovar_Abort PAPRGVPQIEVTFDIDANGIVNVSAKDKGTGKEHQIRIQASGGLSDADIEKMVKDAEANA Desulfotalea_psychrophila_LSv54| TAPRGVPQIEVTFDLDANGILNVSAKDMGTGKEQSIKITASSGLTDEEIDRMTKDAELHA .*: :* . : :. :* : *:..* :*. * * :. Homo_sapiens ------------------------------------------------------------ Synechococcus_sp_RCC307|YP_00122 SVDKEKRERIDLKNQSETLVYQAEKQLSDLGDKVSADDKSKVEGFATQLKEAIEKDDFDT Bacteroides_thetaiotaomicron_ EADKKEREKIDKLNQADSVIFQTENQLKELGDKLPADKKAPIEAALQKLKDAHKSQDLAA Shewanella_sp_MR-4|YP_733094.1 EEDKKFEELVQSRNQADGLVHATKKQVEEAGDALPADDKAKIEAAMSAVEVATKGNDKEA Yersinia_enterocolitica_subsp_en EADRKFEELVQTRNQADHLIHGTRKQLEEAGDKLPAEDKTAIEDAVKALEAALKSEDKAE Brucella_melitensis_biovar_Abort EADKKRRESVEAKNQAESLVHSTEKSLAEYGDKVSADDKKAIEDAIAALKTSLEGEDAED Desulfotalea_psychrophila_LSv54| DEDKKRKELVEARNSADGLIHSTEKTLKDLGDKVDAETKENVEKEIANVKTALEGDDVEA Homo_sapiens ------------------------------------------------------------ Synechococcus_sp_RCC307|YP_00122 MKSVQEELQQALYAAGAAVYQQGADGAAAAA----GGSNGASADSSAAGDDVIDAEFTET Bacteroides_thetaiotaomicron_ IDTAMAEINTVFQTASAEMYAQGGAQGGAQAGPDMDAGQNAGQDNSKHGDNVQDADFEEV Shewanella_sp_MR-4|YP_733094.1 IEKATQELIEASAKLMEIA--QAKAQTQG------GAQEGAAKQSNATADDVVDAEFEEV Yersinia_enterocolitica_subsp_en IEAKTQALVQVSGKLLEMA--QQQAAAGG------DAGDTSAKKE----DDVVDAEFEEV Brucella_melitensis_biovar_Abort IKAKTQALAEVSMKLGQAMY-EAAQAAEG------AGAEGGEQA-SSSKDDVVDADYEEI Desulfotalea_psychrophila_LSv54| IKAAIEALTAASHKLAELMYQQASQETPG------DGDAGAAGAKKKDDDDVVDADYEEV Homo_sapiens ------- Synechococcus_sp_RCC307|YP_00122 K------ Bacteroides_thetaiotaomicron_ K------ Shewanella_sp_MR-4|YP_733094.1 KDDKK-- Yersinia_enterocolitica_subsp_en KDKK--- Brucella_melitensis_biovar_Abort DDNKKSS Desulfotalea_psychrophila_LSv54| K------