MUSCLE (3.7) multiple sequence alignment of the 7 proteins closest to the human query protein. * denotes a perfectly conserved column, and : and . denote well conserved columns. You will notice some regions of very good conservation among all these proteins. M_caseolyticus -----------MTVERWPSHPETASL---------------------------------- B_cereus -----------LTNETFPAEPEKATL---------------------------------- B_anthracis -----MHVDEKLTNETFPAEPEKATL---------------------------------- B_pseudomallei -------------SAAVGLLIMLGSFALWVNGEPWAPYTA-----------------LVG A_borkumensis --------YYVPESSPWPLTASIGLFMTAIGGAHFIQQSTMADME---PSFIGKPLFFLG A_tumefaciens -THQKNHDYHIIDPSPWPLLASIGAFIMTFGGVCYMRYLSGGSFKLFGAELANPWLFYIG E_sibiricum DTHQKNHDYHIIDPSPWPLLASIGAFIMTFGGVCYMRYLSGGSFKLFGAELANPWLFYIG H_sapiens MTHQ-SHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMT-------------LLMLG . : M_caseolyticus ---------------------EGKNKLL-------GFWIFLGGETALFASLFATYL---- B_cereus ---------------------EGKNKFV-------GFWLFLGGETVLFASLFGTYL---- B_anthracis ---------------------EGKNKFV-------GFWLFLGGETVLFASLFGTYL---- B_pseudomallei LLWLLFVLYHWFGDAIAESE-GGMYGKRVDKSYRWSMSWFIFSEVMFFGAFFGALFYAR- A_borkumensis LTWLLVVIALWWRDTIKESV-GGLHSNQLGGSYRQGMLWFIFSEVMFFAAFFGAMFYTRW A_tumefaciens LVIVLYVMYAWWADTIKEAN-EGSHTRVVSLHLRYGMIMFIASEVMFFVAWFWAYFDAS- E_sibiricum LVIVLYVMYAWWADTIKEAN-EGSHTRVVSLHLRYGMIMFIASEVMFFVAWFWAYFDAS- H_sapiens LLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSS- * .: *: .*. :* . * : M_caseolyticus ----------------ALKDHV----------PSEDHLLAKDLFHLPLAFVMTMLLLTSS B_cereus ----------------ALKNSTNGG-------PSS-----QEMFQMPLVFIMTMLLLTSS B_anthracis ----------------ALKNSTNGG-------PTS-----QEMFQMPLVFIMTMLLLTSS B_pseudomallei ----EIAMHQLGSLDYKLIWPDFSAVWP-NEGPGALVGHFKTMGPWPIPTLNTALLLSSG A_borkumensis LILPWLSGEGSNAMTHELLWPNFQAMWPLTVTPAGDT--TQAMGAWGLPAINTAILLVSS A_tumefaciens ----LFPHEAIQ----ASRLEYTGGQWP----PKG----IEVIDPWHLPLYNTVILLLSG E_sibiricum ----LFPHEAIQ----ASRLEYTGGQWP----PKG----IEVIDPWHLPLYNTVILLLSG H_sapiens ----------------LAPTPQLGGHWP----PTG----ITPLNPLEVPLLNTSVLLASG * : : * :** *. M_caseolyticus LTSVYALYHMKNYDFKKMITWLIITVLLGLGFLGLEIYEFVEYVHK-GHTFRSSAFGSAF B_cereus LTSVYAMYHMKNFHFKQMQLWLLVTVLLGLGFLGFEIYEFYHYAHEFKHTMRSSAFGSAF B_anthracis LTSVYAMYHMKNFNFKKMQLWLLVTVLLGLGFLGFEIYEFYHYAHEFKHTMRSSAFGSAF B_pseudomallei ATLTVSHHALREDHRGKAIAWLAATLVLGVCFLFLQGFEYFHAYNELNLTLGSGVYGSTF A_borkumensis VTLTIAHHALLEGKRGTVIAFQAATVILGVIFLFLQVEEYIHAYTELGLTLDAGIYGSLF A_tumefaciens TCVTWAHHALLHNDRKGLISGLALTVALGVLFSTVQVYEYIHA----PFDFKNSIYGATF E_sibiricum TCVTWAHHALLHNDRKGLISGLALTVALGVLFSTVQVYEYIHA----PFDFKNSIYGATF H_sapiens VSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASEYFES----PFTISDGIYGSTF . : : : *: **: * .: *: : . :*: * M_caseolyticus YFLVGTHGFHVIIGLTWIILLIVRNMKRGLSVYNAAKFNTAALYWHFIDVVWVFIFTVVY B_cereus YALVGTHGLHVLFGLCWILTLIFRNAKRGLNLYNAPKFYVASIYWHFIDVVWVFIFTVVY B_anthracis YALVGTHGLHVLFGLCWILTLIFRNAKRGLNLYNAPKFYVASIYWHFIDVVWVFIFTVVY B_pseudomallei FLLTGFHGFHVFLGGTMLAVVLARMIRGHFKPDHHFAFEGAAWYWHFVDVVWLGLYVVVY A_borkumensis FLLTGFHGAHVTIGTIFLFVTLLRVIKGHFDEENNFAWEAGAWYWHFVDVVWLFLFITVY A_tumefaciens FMATGFHGFHVFVGTVFLLVCLFRAIAGGFTPKQHFGFEAAAWYWHFVDVVWLFLFFAIY E_sibiricum FMATGFHGFHVFVGTVFLLVCLFRAIAGGFTPKQHFGFEAAAWYWHFVDVVWLFLFFAIY H_sapiens FVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIY : .* ** ** .* : : * : : : .: ****:****: :: :* M_caseolyticus LLG--- B_cereus LMG--- B_anthracis LMG--- B_pseudomallei W----- A_borkumensis W----- A_tumefaciens IWGGWG E_sibiricum IWGGW- H_sapiens WWG---