CLUSTAL 2.0.10 multiple sequence alignment

Alignment of the 8 proteins closest to the human query protein.
* denotes a perfectly conserved column, and : and . denote well conserved columns. 
You will notice some regions of very good conservation among all these proteins. 


Brucella_suis                 MADVHQKNHDYHIIAPSPWPFLSSVGAFVLAIGGIAWMRYINAGELPFFG 50
Brucella_abortus              MADVHQKNHDYHIIAPSPWPFLSSVGAFVLAIGGIAWMRYINAGELPFFG 50
Mesorhizobium_sp.             MADAHAKKHDYHIIDPSPWPFIASVGALVMALGAIAWMKAAQGSSFPVFG 50
Nitrobacter_winogradskyi      MATAQVK-HDYHLVDPSPWPIVGATAAFIMAVGAILWMHHMTAAAPIIFG 49
Homo_sapiens                  ---MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMT------ 41
Shewanella_oneidensis         -MTTKHET--YYVPAQSAWPIVGAIGLFLIAFGAGQFVTQLKSGNSGGG- 46
Shewanella_sp.                -MTTKHET--YYVPAQSAWPIVGAIGLFLIAFGAGHFVHQLKSGASGGG- 46
Burkholderia_phymatum         -MSGQNESPYYFIPHPSRHPISAAVGLLVMLGSFAAWVN----GEPWAP- 44
                                    :   *.:   *  *: .: . :::  .   :.            

Brucella_suis                 LNVVTP--WIFFIGLAIVLYCMFGWWSDTIKEG-HEGHHTRVVSLHLRYG 97
Brucella_abortus              LNVVTP--WIFFIGLAIVLYCMFGWWSDTIKEG-HEGHHTRVVSLHLRYG 97
Mesorhizobium_sp.             IDLAASRFWLFLIGLLIILYTMFSWWSDTIREG-QEGHHTAVVSLHLRYG 99
Nitrobacter_winogradskyi      ------------IGVVGVLYTMASWWADVIREAEHKGDHTRVVQISHRYG 87
Homo_sapiens                  ---------LLMLGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYG 82
Shewanella_oneidensis         --------YILFAGIAVILFMLVGWFRTVIQES-MTGLYSHQMDRSFRQG 87
Shewanella_sp.                --------YILLAGIVVILFMLVGWFRTVIQES-MTGLYSHQMDRSFRQG 87
Burkholderia_phymatum         --------ITALIGLLWLLFTLYHWFGDAISES-EGGMYGKRVDTSFRWS 85
                                           *:      :  *:  .  *.   * :   :.   * .

Brucella_suis                 MIMFIASEVMFFVAWFWAFFDASLFPN---------EVHQVARAEFTGGV 138
Brucella_abortus              MIMFIASEVMFFVAWFWAFFDASLFPN---------EVHQVARAEFTGGV 138
Mesorhizobium_sp.             MIMFIASELMFFVAWFWAFFDASLFPG---------DPSQVSRAEFTGGT 140
Nitrobacter_winogradskyi      MILFITSEVMFFVAWFWAFFNSALFPG---------DPVHVTREALFGGV 128
Homo_sapiens                  MILFITSEVFFFAGFFWAFYHSSLAP-----------------TPQLGGH 115
Shewanella_oneidensis         MSWFIFSEVMFFAAFFGALFYARMFAVPWLGGASNNAMTHEVLWPNFEAV 137
Shewanella_sp.                MSWFIFSEVMFFAAFFGALFYARMVAVPWLGGASNNAMTHEVLWPHFEAV 137
Burkholderia_phymatum         MSWFIFSEVMFFGAFFGALFYAREIAMHQLG-----SLDYKLIWPDFTAV 130
                              *  ** **::** .:* *:: :   .                      . 

Brucella_suis                 WPPKG-------IEVLDPLH-LPLYNTVILLLSGTTLTWAHHALLHNDRK 180
Brucella_abortus              WPPKG-------IEVLDPLH-LPLYNTVILLLSGTTLTWAHHALLHNDRK 180
Mesorhizobium_sp.             WPPHG-------VEVLDPFH-LPLYNTIILLLSGTTVTWAHHALLENDRK 182
Nitrobacter_winogradskyi      WPPKG-------IQTFDPWH-LPLLNTLILLTSGTTVTWAHHALLNGDRK 170
Homo_sapiens                  WPPTG-------ITPLNPLE-VPLLNTSVLLASGVSITWAHHSLMENNRN 157
Shewanella_oneidensis         WPLLTTPDGTK--TEAMPWNGLPLINTIVLLTSSVTLHFAHISLEKGKRS 185
Shewanella_sp.                WPLLTTPDGTK--TEAMPWNGLPLVNTIVLLTSSVTLHFAHTSLEKGKRS 185
Burkholderia_phymatum         WPNIGPADLVSHFKSMTPWP-VPTINTALLLSSGATLTVSHHALRDNHRT 179
                              **               *   :*  ** :** *..::  :* :* ...*.

Brucella_suis                 GMITGLAITVALGVLFSCVQAYEYIHAP----FAFKDSIYGATFFMATGF 226
Brucella_abortus              GMITGLAITVALGVLFSCVQAYEYIHAP----FAFKDSIYGATFFMATGF 226
Mesorhizobium_sp.             GLVAGLAVTVALGILFSFVQAYEYMHAP----FAFSDSIYGATFFMATGF 228
Nitrobacter_winogradskyi      GLKWGLILTIALGAIFTCVQAYEYQHAA----FSFAGNVYGATFFMATGF 216
Homo_sapiens                  QMIQALLITILLGLYFTLLQASEYFESP----FTISDGIYGSTFFVATGF 203
Shewanella_oneidensis         AITLWLGLTILLGIGFLALQVAEYRHAYEEMGLTLTSGIYGNTFFLLTGF 235
Shewanella_sp.                AITLWLGLTILLGISFLALQAEEYSHAYHEMGLTLTSGVYGNTFFLLTGF 235
Burkholderia_phymatum         KAIAWLAATLVLGVSFLFLQGFEYFHAYNELNLTLASGVYGSTFFLLTGF 229
                                   *  *: **  *  :*  ** .:     ::: ..:** ***: ***

Brucella_suis                 HGFHVLIGTIFLLVCLFRAIGGDFTPKQHFGFEAAAWYWHFVDVVWLFLF 276
Brucella_abortus              HGFHVLIGTIFLLVCLFRAIGGDFTPKQHFGFEAAAWYWHFVDVVWLFLF 276
Mesorhizobium_sp.             HGFHVIVGTIFLAVCLLRAMAGQFTPKQHFGFEAAAWYWHFVDVVWLFLF 278
Nitrobacter_winogradskyi      HGFHVLVGTIFLIVCLFRANAGHFTPSQHLGFEFAAWYWHFVDVVWLFLF 266
Homo_sapiens                  HGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLY 253
Shewanella_oneidensis         HGMHVTLGTIFLLVLFFRVLKGHFSADKHFAFQAGSWYWHFVDVVWLCLF 285
Shewanella_sp.                HGMHVTLGTIFLLVLFFRVLKDHFSADKHFVFQAGSWYWHFVDVVWLCLF 285
Burkholderia_phymatum         HGFHVFLGGTMLAVVLVRLIRGHFTADHHFAFEGAAWYWHFVDVVWLGLY 279
                              **:** :*  :* : :.*    .*:..:*: *: .:*********** *:

Brucella_suis                 FAIYVWGGWGAPMHGG-- 292
Brucella_abortus              FAIYVWGGWGAPMHGG-- 292
Mesorhizobium_sp.             AFIYVWASAGATIAH--- 293
Nitrobacter_winogradskyi      VCIYIWGNGAAAMAHAAH 284
Homo_sapiens                  VSIYWWG----------- 260
Shewanella_oneidensis         IFVYVL------------ 291
Shewanella_sp.                IFVYVL------------ 291
Burkholderia_phymatum         VVVYWL------------ 285
                                :*