Your Protecting Groups Notebook

We know there are just way too many protecting groups in organic chemistry for anyone to memorize. So here is a notebook for you!

Trimethylsilyl Groups

trimethylsilyl structure

Functional Groups: alcohol

Deprotection Condition: Acidic

Triisopropylsilyl Groups

triisopropylsilyl structure

Fuctional Groups: alcohol

Deprotection Condition: Acidic

Benzyl Groups

benzyl structure

Fuctional Groups: alcohol

Deprotection Condition: Hydrogenation, Leweis Acid, Reduction

F-moc Groups

f-moc structure

Fuctional Groups: amine

Deprotection Condition: Basic

Trifluoroacetyl Groups

trifluoroacetyl structure

Fuctional Groups: amine

Deprotection Condition: TFA

Methoxyethoxymethyl Ethers

methoxyethoxymethyl structure

Fuctional Groups: alcohols

Deprotection Condition: Acidic

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