MUSCLE (3.7) multiple sequence alignment of 10 proteins close to the human query protein.
* denotes a perfectly conserved column, and : and . denote well conserved columns. 
You will notice some regions of good conservation among all these proteins. 


P.heparinus         ------------------------------------------------------------
M.caseolyticus      ----------------MTVERWPS------------------------------------
B.cereus            ----------------LTNETFPA------------------------------------
B.anthracis         ----------MHVDEKLTNETFPA------------------------------------
F.tularensis        ----------------VTAEHN--------------------------------------
C.koseri            ----------------MATDTLAQTHATAHA-----------------------------
K.sedentarius       ----------------PVTRPNMA------------------------------------
B.pseudomallei      SAAVGLLIMLGSFALWVNGEPWAPYTAL--------------------------------
A.borkumensis       -------------YYVPESSPWPLTASIGLFMTAIGGAHFIQQSTMA---DMEPSFIGKP
E.sibiricum         -----DTHQKNHDYHIIDPSPWPLLASIGAFIMTFGGVCYMRYLSGGSFKLFGAELANPW
H.sapiens           -----MTHQ-SHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMT-------------
                                                                                

P.heparinus         -----------------------------------KPKKFVLWLFVVSSTIMFGGWT-SY
M.caseolyticus      --------------------------HPETASLEGKNKLLGFWIFLGGETALFASLF-AT
B.cereus            --------------------------EPEKATLEGKNKFVGFWLFLGGETVLFASLF-GT
B.anthracis         --------------------------EPEKATLEGKNKFVGFWLFLGGETVLFASLF-GT
F.tularensis        --------------------------HHHEHHFDGSKNVFGFWIYIMSDCVLFATLF-AT
C.koseri            --------------------------HEHGHHDAGQTKIFGFWIYLMSDCILFSILF-AT
K.sedentarius       --------------------------------------AVGTIVWLGSELMFFAGLF-AM
B.pseudomallei      ---VGLLWLLFVLYHWFGDAIAESE-GGMYGKRVDKSYRWSMSWFIFSEVMFFGAFFGAL
A.borkumensis       LFFLGLTWLLVVIALWWRDTIKESV-GGLHSNQLGGSYRQGMLWFIFSEVMFFAAFFGAM
E.sibiricum         LFYIGLVIVLYVMYAWWADTIKEAN-EGSHTRVVSLHLRYGMIMFIASEVMFFVAWFWAY
H.sapiens           LLMLGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAF
                                                                :: ..  :*     . 

P.heparinus         YIVFSASK-----------------------------GKGHGLVLPDVF-----IYSTAV
M.caseolyticus      YLALKDHV-----------------------------PSEDHLLAKDLFHLPLAFVMTML
B.cereus            YLALKNST-----------------------------NGGPS--SQEMFQMPLVFIMTML
B.anthracis         YLALKNST-----------------------------NGGPT--SQEMFQMPLVFIMTML
F.tularensis        FAVFHKHT-----------------------------FGGPG--AQELFSLPYVFVETML
C.koseri            YAVLVNGT-----------------------------AGGPT--GKDIFELPFVLVETFL
K.sedentarius       YFTLRAVAPQL--------------------WD---------LHTPSLN-VPFALGNTMI
B.pseudomallei      FYAREIAMHQLG-----SLDYKLIWPDFSAVWP-NEGPGALVGHFKTMGPWPIPTLNTAL
A.borkumensis       FYTRWLILPWLSGEGSNAMTHELLWPNFQAMWPLTVTPAG--DTTQAMGAWGLPAINTAI
E.sibiricum         FDASLFPHEAI---------QASRLEYTGGQWP----PKG----IEVIDPWHLPLYNTVI
H.sapiens           YHSSLAPTPQL-----------------GGHWP----PTG----ITPLNPLEVPLLNTSV
                    :                                              :         * :

P.heparinus         LVASSICLFLASRALKVGNTG--------------SQKLFLWATMALGCVFAYLQFDAWS
M.caseolyticus      LLTSSLTSVYALYHMKNYDFK--------------KMITWLIITVLLGLGFLGLEIYEFV
B.cereus            LLTSSLTSVYAMYHMKNFHFK--------------QMQLWLLVTVLLGLGFLGFEIYEFY
B.anthracis         LLTSSLTSVYAMYHMKNFNFK--------------KMQLWLLVTVLLGLGFLGFEIYEFY
F.tularensis        LLISSFIFGLAMLNRNSENIN--------------HVIKFLWITFFLGLGFIIMEVHEFY
C.koseri            LLFSSITYGMAAIAMHKDNKS--------------QVVSWLALTFLFGAGFIGMEIYEFH
K.sedentarius       LVISSV---WCQLGVMKAEHGQSSRTGSLLQVGKWGMREWYVLTYIFGSVFIAGQVFEYA
B.pseudomallei      LLSSGATLTVSHHALREDHRG--------------KAIAWLAATLVLGVCFLFLQGFEYF
A.borkumensis       LLVSSVTLTIAHHALLEGKRG--------------TVIAFQAATVILGVIFLFLQVEEYI
E.sibiricum         LLLSGTCVTWAHHALLHNDRK--------------GLISGLALTVALGVLFSTVQVYEYI
H.sapiens           LLASGVSITWAHHSLMENNRN--------------QMIQALLITILLGLYFTLLQASEYF
                    *: *.     .                                *  :*  *   :   : 

P.heparinus         VLFHTGAAMVNNNAAISMIYIVSGFHLLHIFAGLCIVLNALIGAY-KEMSLEQRKYRMEI
M.caseolyticus      EYVHK-GHTFRSSAFGSAFYFLVGTHGFHVIIGLTWIILLIVRNM-KRGLSVYNAAKFNT
B.cereus            HYAHEFKHTMRSSAFGSAFYALVGTHGLHVLFGLCWILTLIFRNA-KRGLNLYNAPKFYV
B.anthracis         HYAHEFKHTMRSSAFGSAFYALVGTHGLHVLFGLCWILTLIFRNA-KRGLNLYNAPKFYV
F.tularensis        ELAIE-GHTWSSSAFLSSFFTLVGTHGLHVSMGLIWIVSMIFQLK-KYGMNPMAKTKLTY
C.koseri            HLIVE-GMGPDRSGFLSAFFALVGTHGLHVTSGLIWMAVLMVQIA-RRGLTSTNRTRIMC
K.sedentarius       ELVHE-GFTLQTDSYTSIFYLATGFHGIHVLGGLMAFLLIIGRTFTTRHYSHSQATGAIV
B.pseudomallei      HAYNELNLTLGSGVYGSTFFLLTGFHGFHVFLGGTMLAVVLARMI-RGHFKPDHHFAFEG
A.borkumensis       HAYTELGLTLDAGIYGSLFFLLTGFHGAHVTIGTIFLFVTLLRVI-KGHFDEENNFAWEA
E.sibiricum         HA----PFDFKNSIYGATFFMATGFHGFHVFVGTVFLLVCLFRAI-AGGFTPKQHFGFEA
H.sapiens           ES----PFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQL-MFHFTSKHHFGFEA
                                .   : ::   * *  *:  *   .   :                   

P.heparinus         ASIFWHFIDILWIYLYV--------
M.caseolyticus      AALYWHFIDVVWVFIFTVVYLLG--
B.cereus            ASIYWHFIDVVWVFIFTVVYLMG--
B.anthracis         ASIYWHFIDVVWVFIFTVVYLMG--
F.tularensis        LGLFWHFLDIVWIFVFSIVYLLG--
C.koseri            LSLFWHFLDVVWICVFTVVYLMG--
K.sedentarius       TSYYWHFVDVVWIVLFASIY-----
B.pseudomallei      AAWYWHFVDVVWLGLYVVVYW----
A.borkumensis       GAWYWHFVDVVWLFLFITVYW----
E.sibiricum         AAWYWHFVDVVWLFLFFAIYIWGGW
H.sapiens           AAWYWHFVDVVWLFLYVSIYWWG--
                     . :***:*::*: ::